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. 2018 Oct 15;13(10):e0205428. doi: 10.1371/journal.pone.0205428

Table 2. Results of time-varying cox regression models for stroke in the eligible population.

Model 1 Model 2 Model 3
Time-varying Covariate
Cranial Nerve Palsy 4.65 (3.73–5.79) 2.21 (1.77–2.75) 1.70 (1.37–2.12)
Demographics
Sex
    Men N/A 1 (reference) 1 (reference)
    Women N/A 0.73 (0.71–0.75) 0.72 (0.70–0.74)
Age Group (years)
    20–39 N/A 1 (reference) 1 (reference)
    40–59 N/A 6.01 (5.64–6.40) 4.26 (3.99–4.54)
    60+ N/A 31.85 (29.98–33.83) 15.11 (14.15–16.13)
Residence
    Seoul and Incheon N/A 1 (reference) 1 (reference)
    Gyeonggi and Gangwon N/A 1.16 (1.10–1.21) 1.14 (1.09–1.19)
    Busan, Daegu, Ulsan, and Gyeongsang N/A 1.32 (1.26–1.38) 1.38 (1.32–1.44)
    Daejeon, Sejong, and Chungcheong N/A 1.26 (1.19–1.32) 1.26 (1.19–1.33)
    Gwangju, Jeola, and Jeju N/A 1.25 (1.19–1.31) 1.27 (1.21–1.34)
House Income
    Low income N/A 1 (reference) 1 (reference)
    Middle income N/A 0.92 (0.89–0.96) 0.89 (0.86–0.92)
    High income N/A 0.88 (0.85–0.91) 0.83 (0.80–0.86)
Covariates
    Hypertension N/A N/A 2.52 (2.42–2.62)
    Diabetes N/A N/A 1.29 (1.24–1.33)
    Ischemic Heart Disease N/A N/A 1.11 (1.07–1.16)
    Congestive Heart Failure N/A N/A 1.29 (1.23–1.35)
    Cancer N/A N/A 1.00 (0.95–1.04)
    Tuberculosis N/A N/A 1.02 (0.95–1.08)
    Peripheral Arterial Disease N/A N/A 1.15 (1.11–1.20)
    Atrial Fibrillation N/A N/A 1.79 (1.68–1.91)
    Chronic Kidney Disease N/A N/A 1.55 (1.42–1.70)
    Dyslipidemia N/A N/A 0.93 (0.89–0.96)
Co-medications
    Anti-coagulant agents N/A N/A 1.11 (0.89–1.39)
    Anti-hypertensive agents N/A N/A 0.91 (0.87–0.95)
    Anti-platelet agents N/A N/A 1.03 (0.93–1.14)
    Hypoglycemic agents N/A N/A 2.57 (0.83–7.96)

Model 3 included Charlson comorbidity index in the analysis