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. 2018 Jul 9;26(11):1603–1610. doi: 10.1038/s41431-018-0208-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Schematic representation of the CALR3 gene and corresponding protein domains: signal peptide (gray), N-domain (blue), P-domain (orange) and C-domain (yellow). Boxes represent exons; connecting lines represent intervening introns (unscaled). Rare heterozygous CALR3 variants identified in this study are indicated in black. Variants reported by Chiu et al. are indicated in red font. The regions recognized by the primary antibodies used in this study are shown below the graph