Fig. 1. Plasmin(ogen) is a key factor for the development of radiodermatitis.

Representative photographs of the dorsal skin of three different plg+/+ (a), plg+/− (b), and plg−/− mice (c) at different time points after irradiation. Typical irradiated areas are marked on the photographs of the control plg+/− mice taken on day 0. Arrows show the wounds on the skin. d A comparison of the quality of dorsal skin in plg+/+ (n = 6), plg+/− (n = 6), and plg−/− (n = 6) mice at day 14 after irradiation. The skin damage scores are 0 = normal skin, 1 = erythema, 2 = desquamation, and 3 = ulceration. The mean values are indicated (black lines) and SEM is shown. *P < 0.05