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. 2018 Oct 15;9(11):1051. doi: 10.1038/s41419-018-1106-8

Fig. 5. Plasmin activity is necessary for the development of radiodermatitis.

Fig. 5

a Representative photographs of the dorsal skin of the tPA−/−;uPA−/− mice at different time points after irradiation. b Plasminogen levels in skin extracts from tPA+/+;uPA+/+ mice and tPA−/−;uPA−/− mice after irradiation measured by ELISA. c–g RT-PCR measurement of mRNA levels of IL1-β (c), IL-6 (d), TNFα (e), TGF-β (f), and PAI-1 (g) in irradiated skin of plg+/+, plg−/−, and tPA−/−;uPA−/− mice. *P < 0.05; **P < 0.01; ***P < 0.005