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. 2018 Oct 15;9(11):1051. doi: 10.1038/s41419-018-1106-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — plg+/+ and plg+/− mice were treated with TXA in their drinking water from 2 days before irradiation until day 10 post irradiation. Control mice were irradiated but did not receive TXA. a, b Representative photographs of the dorsal skin of irradiated plg+/+ mice treated with TXA, and a comparison of the quality of the dorsal skin in irradiated control and TXA-treated plg+/+ mice (n = 6 per time point). c, d Representative photographs of the dorsal skin of irradiated plg+/− mice treated with TXA, and a comparison of the quality of the dorsal skin in irradiated control and TXA-treated plg+/− mice (n = 6 per time point). Arrows show the wounded skin area. e Plasminogen levels in the skin extracts of control and TXA-treated plg+/+ mice on different days after irradiation. f–j RT-PCR measurement of mRNA levels of IL1-β (f), IL-6 (g), TNF-α (h), TGF-β (i), and PAI-1 (j) in the irradiated skin of control and TXA-treated plg+/+ and in plg−/− mice on different days after irradiation. *P < 0.05; **P < 0.01; ***P < 0.005; ****P < 0.001.