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. 2018 Oct 15;9:4268. doi: 10.1038/s41467-018-06739-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — HBV genome contacts preferentially CpG-rich regions. a Proportion of HBV contacts with a given biological element (as indicated along with the number of elements) compared with the corresponding null model that shows the distribution using the Hi-C coverage of the corresponding library and represented by violin plot. Density plot width = frequency, line = 95% confidence interval, box plot = interquartile range. Red dot represents the proportion of HBV contacts that overlap with the indicated biological element (computed in windows ± 3.5 kb around the start of the read). p-values were determined according to the percentages detected in the bootstrap strategy (see Methods). b Proportion of HBV contacts with CGIs grouped according to their relative distance to TSS (computed in windows ± 3.5 kb around the start of the read) compared with the corresponding null model that shows the distribution using the Hi-C coverage and represented using the violin plot. Density plot width = frequency, line = 95% confidence interval, box plot = interquartile range. Red dot represents the proportion of HBV contacts that overlap with the indicated biological element (computed in windows ± 3.5 kb around the start of the read). p-values were determined according to the percentages detected in the bootstrap strategy (see Methods)