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. 2018 Oct 15;9:4268. doi: 10.1038/s41467-018-06739-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — HBV contacts are enriched at GCIs associated with highly expressed genes and deregulated genes. a Heatmap of downregulated and upregulated genes in HBV infected PHH 399 compared with mock-infected PHH 399 and KEGG enrichment analysis. b Proportion of HBV contacts that overlap with CGIs present in the promoter of genes pooled according to their functional annotation (as indicated along with the number of elements) compared with the corresponding null model that shows the distribution using the Hi-C coverage and represented by violin plot. Density plot width = frequency, line = 95% confidence interval, box plot = interquartile range. Red dots represent the proportion of HBV contacts with the indicated biological element (computed in windows ± 3.5 kb around the start of the read). p-values were determined according to the percentages detected in the bootstrap strategy (see Methods)