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. 2018 Oct 15;8:15254. doi: 10.1038/s41598-018-33498-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of gene expression and promoter methylation data between the TCGA data analyzed and those of independent biological experiments. (A) Scatter plots showing the correlation of expression levels of genes from TCGA data which were differentially methylated (HSF4, MYO15B and SERINC4; y-axes) with SYCP2 (x-axes). The yellow circles represent HPV− samples, while the green triangles represent HPV+ counterparts. (B) Comparison of the methylation levels of the promoter region (TSS200) between HPV+ and HPV− samples in external high-throughput methylation experiments. The adjusted p-values that remained significant are shown.