Table 4.
Descriptions of the cellular functions of genes after exposure to MUA/Au NPs = 3.
| Gene expression after exposure to MUA/Au NPs = 3 | |
|---|---|
| Upregulated genes | |
| Y65B4BR.1 | Y65B4BR.1 is an ortholog of human PLB1 (phospholipase B1); Y65B4BR.1 is involved in cellular defense response; Y65B4BR.1 is predicted to have hydrolase activity, acting on ester bonds, based on protein domain information. |
| fil-1 | fil-1 is involved in lipid catabolic processes and lipid storage; fil-1 exhibits lipase activity; fil-1 is expressed in the intestine. |
| clec-174 | clec-174 is involved in cellular defense response. |
| F49C12.7 | RNA sequencing and microarray studies indicate that F49C12.7 is regulated by ethanol, 1-methylnicotinamide, methylmercuric chloride, D-glucose, chlorpyrifos, diazinon, humic substances, R24, colistin, dafa #1, and sirolimus; proteomic, tiling array, RNA sequencing, and microarray studies indicate that F49C12.7 is enriched in the germ line, coelomocytes, the intestine and neurons. |
| cysl-2 | cysl-2 encodes a homolog of sulfhydrylases/cysteine synthases. |
| Downregulated genes | |
| mtl-1 | mtl-1 encodes one of two C. elegans metallothioneins, small, cysteine-rich metal-binding proteins; MTL-1 functions in metal detoxification, homeostasis and stress adaptation; in addition, mtl-1 plays a role in regulating growth and fertility; mtl-1 is constitutively expressed in the terminal bulb of the pharynx and its expression is induced in larval intestinal cells following exposure to cadmium and heat shock and repressed in response to P. aeruginosa infection; intestinal expression is dependent on ELT-2, an intestine-specific GATA-type transcription factor; mtl-1 is upregulated by DAF-16 in daf-2 mutants. |
| ZK593.3 | ZK593.3 is involved in lipid storage. |
| F44A6.5 | F44A6.5 encodes a novel protein conserved among nematodes. |
| T05E12.6 | T05E12.6 is an ortholog of human EPHX1 (epoxide hydrolase 1); microarray and RNA sequencing studies indicate that T05E12.6 is regulated by heme, diallyl trisulfide, tunicamycin, D-glucopyranose, D-glucose, deoxyglucose, atrazine, fluoranthene, Cry5B, chlorpyrifos, Diazinon, quercetin, humic substances, colistin, adsorbable organic bromine compounds, sirolimus, and Ag nanoparticles; RNA sequencing and microarray studies indicate that T05E12.6 is enriched in germ line cells, intestine, and I5, DA, SAB, and retrovesicular ganglia. |
| T05E12.6 | T05E12.6 is an ortholog of human EPHX1 (epoxide hydrolase 1); microarray and RNA sequencing studies indicate that T05E12.6 is regulated by heme, diallyl trisulfide, tunicamycin, D-glucopyranose, D-glucose, deoxyglucose, atrazine, fluoranthene, Cry5B, chlorpyrifos, diazinon, quercetin, humic substances, colistin, adsorbable organic bromine compounds, sirolimus, and Ag nanoparticles; RNA sequencing and microarray studies indicate that T05E12.6 is enriched in germ line cells, intestine, and I5, DA, SAB, and retrovesicular ganglia. |
Information taken from Wormbase (Wormbase.org). For additional details and citations, please refer to Wormbase.