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. 2018 Oct 15;8:15226. doi: 10.1038/s41598-018-33149-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Administration of NaHS ameliorates HHcy induced NF-κB acetylation dependent proinflammatory response in CBS^+/− mice. (a,b) Protein western blot analysis confirmed that NF-κB acetylation (p65) activity was present at the K310 region of CBS-deficient mice. (c) CBS^+/− mice derived BMMSCs culture was transfected with pGL4.32[luc2P/NF-jB-RE/Hygro] vector, for the first 48 hours. Increased luciferase activity was observed in CBS^+/− mice derived BMMSCs. (d) Plasma inflammatory cytokine levels were measured in the experimental mice using ELISA. (e) qPCR was performed for the osteogenic gene transcripts: OCN and RunX2. Experiments were repeated three times. Data are expressed as mean ± SEM. n = 5 mice per group. *p < 0.05 compared with the WT mice, ^#p < 0.05 compared with the CBS^+/− mice.