Fig. 8.

A summary model. A scheme of potential model how FcR and PIP2 redistribution-based mechanisms can share the entire signaling cascade downstream of ITAM for phagocytosis. When solid particles are engaged with plasma membrane, the binding induces membrane curvature change and sorting of PIP2 at the site of contact. This leads to the membrane recruitment of Moesin and its activation. Binding of Syk to Moesin consequently leads to all downstream phagocytic signaling and actin polymerization. On the other hand, during receptor-mediated phagocytosis, opsonized particles engage Fc receptors on the cell surface; ITAM of FcR becomes phosphorylated. This leads to the recruitment of Syk and all downstream phagocytic signaling identical to the lipid-based phagocytosis