Table 2.
AUC values with 95% confidence intervals for the logistic regression models
| Variable 1 | Variable 2 | Charité | Finland | ||||
|---|---|---|---|---|---|---|---|
| All | Stage I/II | Stage III/IV | All | Stage I/II | Stage III/IV | ||
| CA 125/Glc/GalCer(d18:1/26:0) | Cer(d18:1/24:1)/LPC 14:0_sn2 | 0.93 (0.89–0.96) | 0.87 (0.80–0.94) | 0.98 (0.96–1.00) | 0.76 (0.68–0.85) | 0.74 (0.64–0.83) | 0.93 (0.84–1.00) |
| Cer(d18:1/24:1)/LPC 14:0_sn2 | CA 125/PC 37:2 | 0.93 (0.89–0.96) | 0.87 (0.81–0.94) | 0.98 (0.95–1.00) | 0.76 (0.68–0.85) | 0.73 (0.64–0.83) | 0.95 (0.89–1.00) |
| Cer(d20:1/24:1)/LPC 14:0_sn2 | CA 125/PC 37:2 | 0.92 (0.87–0.96) | 0.85 (0.77–0.93) | 0.98 (0.95–1.00) | 0.77 (0.68–0.85) | 0.74 (0.64–0.83) | 0.95 (0.90–1.00) |
| Cer(d18:1/24:1)/LPC 14:0_sn2 | CA 125/PI 38:2 | 0.92 (0.89–0.96) | 0.87 (0.81–0.94) | 0.97 (0.94–1.00) | 0.77 (0.69–0.85) | 0.75 (0.66–0.84) | 0.95 (0.88–1.00) |
| CA 125 | TAG(18:1/18:1/22:6)/LPC 14:0_sn2 | 0.91 (0.86–0.96) | 0.83 (0.73–0.92) | 0.98 (0.96–1.00) | 0.78 (0.70–0.86) | 0.75 (0.66–0.84) | 0.89 (0.77–1.00) |
| TAG(18:1/18:1/22:6)/LPC 14:0_sn2 | CA 125/PC 37:2 | 0.91 (0.86–0.96) | 0.83 (0.74–0.91) | 0.98 (0.96–1.00) | 0.78 (0.70–0.86) | 0.75 (0.66–0.84) | 0.88 (0.73–1.00) |
| TAG(18:1/18:1/22:6)/LPC 14:0_sn2 | CA 125/PC P-34:2 + 1 | 0.91 (0.86–0.96) | 0.83 (0.75–0.92) | 0.98 (0.96–1.00) | 0.78 (0.70–0.86) | 0.75 (0.66–0.84) | 0.89 (0.75–1.00) |
| TAG(18:1/18:1/22:6)/LPC 14:0_sn2 | CA 125/SM 37:2 | 0.91 (0.86–0.95) | 0.83 (0.73–0.92) | 0.98 (0.96–1.00) | 0.78 (0.70–0.86) | 0.75 (0.66–0.84) | 0.91 (0.80–1.00) |
| Cer(d20:1/24:1)/LPC 14:0_sn2 | CA 125/PI 38:2 | 0.91 (0.87–0.96) | 0.85 (0.76–0.93) | 0.97 (0.94–1.00) | 0.78 (0.70–0.86) | 0.76 (0.67–0.85) | 0.95 (0.88–1.00) |
| TAG(18:1/18:1/22:6)/PC 30:0 | CA 125/PC 30:0 | 0.90 (0.85–0.95) | 0.82 (0.73–0.91) | 0.98 (0.95–1.00) | 0.79 (0.72–0.87) | 0.77 (0.68–0.85) | 0.91 (0.78–1.00) |
| CA 125 | 0.90 (0.84–0.95) | 0.81 (0.71–0.90) | 0.97 (0.94–1.00) | 0.72 (0.62–0.81) | 0.67 (0.57–0.78) | 0.95 (0.91–1.00) | |
| CA 125 (35 U/mL cutoff) | 0.80 (0.73–0.86) | 0.69 (0.59–0.80) | 0.89 (0.84–0.94) | 0.71 (0.64–0.79) | 0.68 (0.60–0.76) | 0.91 (0.87–0.95) | |
As comparison, the models are shown also for CA 125 alone or CA 125 as binary variable dichotomised by the clinically used 35 U/mL cutoff value