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. 2018 Oct 15;8:15229. doi: 10.1038/s41598-018-33449-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Validation of differential expression for selected metabolite features. (a) CSF metabolite profile of N-acetylneuraminic acid and Unknown 1–6 including Unknown 1 adduct and Unknown 1 fragment for CLN2 and control individuals in ANPneg mode, except for unknown 6 which was only detected in the test cohort with positive ion monitoring (absence of this feature in the validation set (b)). (b) Abundance values of the metabolites of the validation set were normalized by the average fold change of B12, B13, B14, B15, B17, B20 and B26, as quantified on data acquisition days for both the initial case analysis and validation study cases.