Table 2.

Pearson correlation coefficients and p-values of CLN2 signature metabolite abundances (normalized) and the MRIDSS, WCLS or age for all individuals (test and validation cohort).

Identification	Metabolite feature	WCLS		MRIDSS		Age (Months)
		Pearson r	p-value	Pearson r	p-value	Pearson r	p-value
NAAG	Unknown 1	0.74	<0.0001	0.76	<0.0001	−0.7215	0.0002
NAAG-Adduct	Unknown 1 Adduct	0.75	<0.0001	0.78	<0.0001	0.1565	0.1976
Glycero-3-phosphoinositol	Unknown 2	0.6	0.003	0.57	0.0056	−0.5017	0.0174
NANA	N-Acetylneuraminic Acid	0.65	0.0009	0.59	0.0036	−0.3841	0.0776
NANA Dimer	Unknown 3	0.74	<0.0001	0.7	0.0003	−0.4997	0.0179
139.981	Unknown 4 parent	0.65	0.001	0.6	0.0029	−0.3848	0.077
95.988	Unknown 4	0.64	0.0015	0.57	0.006	−0.4181	0.0528
N-Acetylalanine	Unknown 5	0.66	0.0008	0.65	0.001	−0.5332	0.0106
N-Acetylglutamic Acid		0.11	0.6278	0.01	0.9585	−0.2377	0.2867
N-Acetylglycine		0.48	0.0224	0.28	0.2037	−0.37	0.0901
N-Acetylserine		0.67	0.0007	0.72	0.0001	−0.4748	0.0256
N-Acetylthreonine		0.55	0.0079	0.5	0.0175	−0.4243	0.0491