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. 2018 Oct 15;8:15276. doi: 10.1038/s41598-018-33215-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Thermal nociception in adult Drosophila is diminished by Tv1. A thermal heat assay used to measure the antinociceptive effect of Tsu1.1 and Tv1 on adult flies. (A) Schematic representation of the assay measuring thermal nociception. The assay measures the avoidance from a noxious (46 °C) surface. (B) Injection with the higher concentration of Tv1 produced a large reduction in heat avoidance in the first hour: ∆ = −12.33% [95 CI −20.31, −4.39], g = −1.02, p = 0.005, N = 15. Hedges’ g is a standardized effect size. (C) Avoidance behavior in flies injected with two different concentrations of Tsu1.1 resulted in the control flies and the experimental flies displaying a similar heat avoidance. Control data are depicted in grey dots, and teretoxin injected-fly data in orange.