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. 2018 Oct 15;8:15256. doi: 10.1038/s41598-018-33661-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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RAGE deficiency reduced weight gain and visceral adipose tissue but did not affect circulating lipids or monocytosis. (A–C) Bodyweight gain over time in the 12 weeks WTD-feeding experiment (A) and vAT (B) or sAT (C) as percentage of bodyweight. (D) Plasma cholesterol and triglyceride levels after 12 weeks of WTD feeding. (E) Total circulating monocyte levels and subdivision in Ly6c⁺ and Ly6c⁻ monocytes measured by flow cytometry and presented as cells/µl after 12 weeks of WTD feeding. All data are means ± SEM. ^##P < 0.01, ^###P < 0.001 vs WT. n = 11–12.