Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 15;8:15256. doi: 10.1038/s41598-018-33661-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

RAGE deficiency does not affect hepatic steatosis, neutrophil infiltration or macrophage accumulation. (A,B) Representative images of the liver stained with H&E (A; 200x magnification) and hepatic cholesterol and triglyceride levels after 12 weeks of WTD feeding (B). (C) Hepatic inflammation scored (1, 2, 3 or 4) by an experienced pathologist based on lobular inflammation and immune cell numbers after 12 weeks of WTD feeding. (D) Representative photos and quantification of immunohistochemical neutrophil staining (NIMP-R14 antibody; 200x magnification) in the liver after 12 weeks of WTD. (E) Representative images of hepatic macrophage staining (F4/80 antibody; 200x magnification) after 12 weeks of WTD feeding. (F) Total hepatic gene expression levels measured of inflammatory and immune cell specific markers after 12 weeks of WTD feeding. (G) Hepatic GLO-1 activity levels after 12 weeks of WTD feeding. All data are means ± SEM. ^#P < 0.05, ^###P < 0.001 vs WT. n = 11–12. Scalebars 100 µm.