Table 1.
Circulating and hepatic α-dicarbonyls and free AGEs are not affected by RAGE.
| WT (Mean ± SEM) | KO (Mean ± SEM) | |
|---|---|---|
| Plasma MGO (nmol/L) | 1267 ± 238 | 853 ± 125 |
| Plasma GO (nmol/L) | 4953 ± 424 | 5507 ± 266 |
| Plasma 3-DG (nmol/L) | 2595 ± 147 | 2757 ± 176 |
| Hepatic MGO (nmol/g) | 2987 ± 169 | 2930 ± 200 |
| Hepatic GO (nmol/g) | 4676 ± 380 | 4923 ± 477 |
| Hepatic 3-DG (nmol/g) | 11336 ± 1553 | 9980 ± 1404 |
| Plasma CML (nmol/L) | 86,6 ± 6,5 | 74,6 ± 5,6 |
| Plasma CEL (nmol/L) | 21,5 ± 1,1 | 22,7 ± 0,9 |
| Plasma MG-H1 (nmol/L) | 8,4 ± 1,7 | 8,9 ± 1,2 |
| Hepatic CML (nmol/g) | 2,53 ± 0,11 | 2,49 ± 0,08 |
| Hepatic CEL(nmol/g) | 5,28 ± 0,44 | 4,49 ± 0,17 |
| Hepatic MG-H1 (nmol/g) | 0,72 ± 0,06 | 0,63 ± 0,06 |
The α-dicarbonyls MGO, GO and 3-DG measured in plasma and liver after 12 weeks of WTD feeding. In addition, the free CML, CEL and MG-H1 levels in the circulation and the liver after 12 weeks of WTD. n = 11–12.