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. 2018 Oct 9;9:2309. doi: 10.3389/fimmu.2018.02309

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Copyright © 2018 Davydov, Obraztsova, Lebedin, Turchaninova, Staroverov, Merzlyak, Sharonov, Kladova, Shugay, Britanova and Chudakov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Patterns of newly acquired somatic hypermutations in young and middle-age donors vaccinated with YF. (A) Summary profile of somatic hypermutations observed in the study. IGH regions are marked with color. The distribution of silent (S) and replacement (R) hypermutations are shown with dashed and solid lines, respectively. For CDR3 region, mutation analysis was done using the root as reference. Data were pooled for all young and all middle-age individuals. (B) Frequency of newly acquired somatic hypermutations (SHMs) in young (red) and middle-age (blue) donors. ANOVA p = 0.0005 for age, 0.14 for isotype. (C,D) Mean replacement:silent ratio (R:S ratio) for newly acquired somatic hypermutations (SHMs) in young and middle-age donors, for isotypes (C, ANOVA p = 0.058 for age, 0.69 for isotype) and regions (D, ANOVA p = 0.0013 for age, 0.00014 for regions).