Figure 4.

ILC2 intrinsic miR-155 is critical for ILC2 expansion. B6SJL mice were lethally irradiated and received BM from Rora^flox/flox x Il7ra^Cre mice alone or in equal proportions with WT or miR155^−/− BM. After 3 months to allow reconstitution, mice were treated with i.p. IL-33 (1 ug/dose) for 3 days. (A) Representative flow cytometry gating for the indicated populations. (B) Frequency of ILC2 (Lin⁻CD127⁺KLRG1⁺Sca1⁺) from MLN. Numbers of CD4⁺ T cells (C) and B cells (D) from MLN. Data are representative of three independent experiments. *p ≤ 0.05 with ANOVA with Tukey correction.