Table 2.

Summary of input data sources on ACh-mediated effects on the physiology of neocortical synaptic connections.

Connection-type	Short-term dynamics	Experimental technique	Physiological effect	Reference
L23 PC → L23 BC	E2 Excitatory, depressing	Bath-application of ~5 μM of CCh in Rat S1 slices (P11–26)	Reduction of first PSP amplitude to ~60% of control	Levy et al. (2008)
L23 PC → L23 PC	E2 Excitatory, depressing	Bath-application of ~10 μM oxotremorine or muscarine in Rat A1 slices (P21–28)	Decreases first EPSC amplitude to ~53% of control	Atzori et al. (2005)
L4 excitatory → L4 excitatory	E2 Excitatory, depressing	Bath-application of ~100 μM ACh in Rat S1 slices (P18–24)	Diminishes first PSP amplitude to ~40% of control	Eggermann and Feldmeyer (2009)
L5 PC → L5 PC	E2 Excitatory, depressing	Bath-application of ~100–150 μM ACh in Rat S1 slices (P13–15)	Reduction of first PSP amplitude to ~25% of control	Tsodyks and Markram (1997)
L5 PC → L5 PC	E2 Excitatory, depressing	Bath-application of ~200 μM ACh in Rat S1 slices (P13–15)	Decreases first PSP amplitude to ~5% of control	Tsodyks and Markram (1997)