Table 2.

Worldwide availability of genetically modified chickens.

Transgenic chicken	Affiliation of the research group	Country	References
Transgenic chickens carrying a benign defective subgroup A leukosis virus	Avian Disease and Oncology Laboratory, USDA Agriculture Research Service	USA	Salter and Crittenden, 1989; Cao et al., 2015
Transgenic chickens expressing active β-lactamase in the egg white	AviGenics, Inc., Georgia BioBusiness Center, Athens	USA	Harvey et al., 2002
eGFP expressing chickens	The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh	UK	McGrew et al., 2004
	Department of Physiology, Catholic University of Daegu School of Medicine	South Korea	Kwon et al., 2004
	University of Utah School of Medicine, Department of Neurobiology, and Anatomy	USA	Chapman et al., 2005
	Crystal Bioscience/ Ligand Pharmaceuticals Inc	USA	Van De Lavoir et al., 2006
	Technical University Munich, School of Life Sciences Weihenstephan; Department of Animal Sciences, Reproductive Biotechnology	Germany	Trefil et al., 2017
Hens specifically expressing therapeutic proteins in the oviduct	The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh	UK	Lillico et al., 2007
Production of transgenic chickens expressing a tetracycline-inducible eGFP gene	Department of Physiology, Catholic University of Daegu School of Medicine, Daegu	South Korea	Kwon et al., 2011
Short-hairpin RNA against Influenza expressing chickens	Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge	UK	Lyall et al., 2011
Transgenic chickens expressing human extracellular superoxide dismutase	Laboratory of Dermatology-immunology, The Catholic University of Korea	South Korea	Byun et al., 2013
Immunoglobulin heavy chain (JH) KO chickens	Crystal Bioscience/ Ligand Pharmaceuticals Inc	USA	Schusser et al., 2013a
Transgenic chickens expressing the human urokinase type-plasminogen activator	Department of Animal Biotechnology, Bio-Organ Research Center, Konkuk University	South Korea	Lee et al., 2013
CSF1R-receptor reporter chickens	The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh	UK	Balic et al., 2014
Immunoglobulin light chain (IgL) KO chickens	Crystal Bioscience/Ligand Pharmaceuticals Inc	USA	Schusser et al., 2016
Cre-recombinase expressing chickens	Crystal Bioscience/Ligand Pharmaceuticals Inc	USA	Leighton et al., 2016
Ovalbumin and Ovomucoid KO chickens	Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology and Animal Breeding and Reproduction Research Division	Japan	Oishi et al., 2016
Aromatase overexpressing chickens	Department of Anatomy and Developmental Biology, Monash University, Clayton	Australia	Lambeth et al., 2016b
mCherry expressing chickens	Technical University Munich, School of Life Sciences Weihenstephan, Department of Animal Sciences, Reproductive Biotechnology	Germany	Trefil et al., 2017
	BIOPHARM, Research Institute of Biopharmacy and Veterinary Drugs and Institute of Molecular Genetics of the Czech Academy of Sciences	Czech Republic
DDX4 KO chickens	The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh	UK	Taylor et al., 2017
3D8 single chain variable fragment (scFv) expressing chickens	Animal Biotechnology Division, National Institute of Animal Science and Department of Avian Disease Laboratory, College of Veterinary Medicine	South Korea	June Byun et al., 2017
Chickens with humanized immunoglobulin genes	Crystal Bioscience/ Ligand Pharmaceuticals Inc	USA	Ching et al., 2018
Chickens overexpressing human IFN-β	Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology	Japan	Oishi et al., 2018