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. 2018 Oct 9;9:1026. doi: 10.3389/fphar.2018.01026

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Copyright © 2018 Gu, Wu, Su, Xing, Shen, He, Li, Yuan, Tang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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E2 increased the number of lysosomes containing myelin protein P0 in regeneration sciatic nerve. (A) Immunohistochemistry with anti-LAMP1 (green) and anti-P0 (red), obtained at 2 and 3 weeks after surgery, of the regenerating nerve in OVX rats with E2 or vehicle treatment. Also shown are the higher magnifications of the boxed areas. It is worth noting that P0 has high colocalization ratio with LAMP1 in E2-treated group. Scale bars, 200 μm; zoom in, 50 μm. (B,C) The expression of lysosome membrane protein LAMP1 and myelin protein P0 in the regenerating region of E2-treated group was significantly higher than vehicle group. ^∗∗p < 0.01, ^∗∗∗p < 0.001 versus vehicle. Two-way ANOVA, n = 12 slices from 4 rats per group. All the data are mean ± SEM.