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CD9 is necessary for dendritic cell activity. On human DCs, CD9 co-localizes with CD81 and FcεRI, and crosslinking with FcεRI induces IL-10 secretion. CD9 is also physically associated with MHC-II molecules and CD38 in TEMs, and the integrity of these lipid rafts is necessary for antigenic presentation by DCs and dexosome release. CD9 is now mostly known as a specific exosome marker.
