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The changed weighted global brain connectivity (wGCB) in major depressive disorder (MDD) patients. Two-sample t-test was used to compare the wGCB maps between healthy controls (HC) and MDD patients and identified (A) decreased wGCB in left temporal pole (TP) and (B) increased wGCB in right parahippocampus (PHC). The significance was determined using a cluster-level Monte Carlo simulation (5000 times) corrected threshold of p < 0.05 (cluster-forming threshold at voxel-level p < 0.001).
