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. 2018 Oct 9;12:692. doi: 10.3389/fnins.2018.00692

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Copyright © 2018 Zhang, Wu, Xu and Shang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Disrupted functional connectivities in major depressive disorder (MDD) patients. Two-sample t-tests were used to identify the significant differences in functional connectivity between MDD and healthy control groups. (A) Significantly decreased functional connectivity between left temporal pole and right superior temporal gyrus and (B) significantly increased functional connectivity between right parahippocampus and right inferior frontal gyrus were found. The significance was determined using a cluster-level Monte Carlo simulation (5000 times) corrected threshold of p < 0.05 (cluster-forming threshold at voxel-level p < 0.001).