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. 2018 Oct 9;9:1097. doi: 10.3389/fphar.2018.01097

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Copyright © 2018 Zhang, Fan, Cai, Wang, Teng, Lei, Zeng, Gupta and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of olmutinib on intracellular accumulation and efflux of [³H]-MX in NCI-H460 and NCI-H460/MX20 cells. (A) The effects of olmutinib on the accumulation of [³H]-MX in NCI-H460 and NCI-H460/MX20 cells. (B) The effects of olmutinib on the efflux function of NCI-H460 cells. (C) The effects of olmutinib on the efflux function of NCI-H460/MX20 cells. Error bars represent the SD value. Ko 143 (3 μM) is used as positive control for ABCG2-overexpressing cells. ^∗P < 0.05 versus control group, two-way ANOVA.