Figure 2.

Behavioral studies of mice. (A) Depression-like mice had least sucrose preference among the three groups, and ketamine improved sucrose preference performance of depression-like mice. (B) Working memory of depression-like mice was impaired, and ketamine treatment attenuated working memory impairment of depression-like mice. (C) Contextual fear conditioning memory of depression-like mice was impaired, and ketamine attenuated the memory impairment of depression-like mice. Means were showed, and SEM were represented by error bars, n = 12, per group. *P < 0.05, one-way ANOVA, post hoc Tukey-Kramer.