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. 2018 Oct 9;9:2396. doi: 10.3389/fmicb.2018.02396

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Copyright © 2018 Xu, Gu, Chen, Quan, Lv, Chen, Zheng, Xu and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pediococcus pentosaceus LI05 administration attenuated C. difficile-induced colonic tissue damage. (A) Schematic presentation of the experimental design. Mice were randomly assigned to three groups: NC group (N = 8), CDI group (N = 12), and LI05 group (N = 8). (B) Kaplan–Meier survival plots of three groups. (C) Mean relative weight of all surviving mice (up to the day of death). (D) Toxins A and B levels were measured in the fecal samples on day 3 and expressed as test value (ODs). (E) Pathologic score of colonic tissues. NC, normal control; CDI, C. difficile infected; LI05, P. pentosaceus LI05 treated. (F) Representative H&E staining of colonic tissues. The arrows showed epithelial damage (blue), neutrophil margination (red), and congestion/edema (black) (scale bar, 100 μm).