FIG 4.

Schematic diagram of BECN1 with the known Bcl2 homology domain (BH3), coiled-coil domain (CCD), and evolutionarily conserved domain (ECD), which is conserved between mammals and yeast. Known phosphorylation sites are reflected with arrows and italicized numbers of the cognate residues. In red are the kinases that have been reported to phosphorylate that site. In green are phosphatases that are known to act on those specific phosphoresidues. The asterisk reflects a tentative connection of MAPK1/3 to S15 of BECN1 based on the dephosphorylation activity of DUSP1.