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. 2018 Oct 15;38(21):e00249-18. doi: 10.1128/MCB.00249-18

FIG 4.

FIG 4

PCSK3, -5, and -6 catalytic activities are essential for pro-GDF15 cleavage. Representative Western blot images of HL1 medium and cell lysates are shown. HL1 cardiomyocytes were transfected with WT GDF15-mf and an equal amount of plasmids encoding WT or mutant PCSK3 (A), PCSK5 (B), or PCSK6 (C). β-Actin served as a loading control.