FIG 4.
Circulating levels of liver enzymes in serum samples collected weekly from HEV-infected wild-type and HEV-infected JH−/− knockout gnotobiotic piglets. Serum was collected weekly from each piglet beginning with 0 wpi and continuing until necropsy at 4 wpi. Liver enzymes, including AST (A), total bilirubin (B), alkaline phosphatase (C), and GGT (D), were measured at the Iowa State University Veterinary Diagnostic Lab. Normal limits were provided with the analysis based on the laboratory's standards for each specific test, which are indicated on each scatterplot graph as a dotted line. Each sample indicates an individual piglet for each time point and are expressed as means ± the SEM. Analysis was completed using two-way ANOVA (*, P < 0.05).