TABLE 1.
Experimental infection of wild-type and immunoglobulin JH−/− knockout gnotobiotic piglets with a genotype 3 human strain (US2) of hepatitis E virus
| Group | No. of pigletsa | Phenotype of piglets | Inoculab | No. of piglets undergoing necropsy at 4 wpi |
|---|---|---|---|---|
| 1 | 5 | JH knockout | PBS | 5 |
| 2 | 6 | JH knockout | G3 (US2) HEV | 6 |
| 3 | 4 | Wild-type | PBS | 4 |
| 4 | 5 | Wild-type | G3 (US2) HEV | 6 |
a
Piglets were retrieved by hysterectomy at 111 to 113 days of gestation and maintained germfree in sterile isolators for the duration of the study. Variation in piglet numbers per groups was due to the efficiency in retrieval of live piglets following embryo transfer.
b
Piglets were inoculated with US2 strain of HEV or mock infected (PBS) at 8 days of age via ear-vein injection.