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. 2018 Oct 9;12:341. doi: 10.3389/fncel.2018.00341

Figure 6.

Figure 6

Novelty-induced hypoactivity in global Shank3Δ14–16 and Viaat-Cre;Shank3Δ14–16 mice. (A) Suppressed locomotor activity, as measured by distance moved in Shank3Δ14–16 mice (11–13 weeks) in the open-field test. Data are shown as mean ± SEM. n = 23 (WT) and 22 (KO), **P < 0.01, ***P < 0.001, repeated measures two-way ANOVA (genotype p value < 0.0001; genotype × time interaction p value = 0.0109) and Student’s t-test. (B) Shank3Δ14–16 mice (9–14 weeks) show suppressed locomotor activity during an early period (first 2 and 6 h), but not in the later habituated period (last 72 h), in Laboras cages (long-term monitoring). n = 20 (WT) and 21 (KO), *P < 0.05, ***P < 0.001, repeated measures two-way ANOVA (genotype p value = 0.3711; genotype × time interaction p value < 0.0001) and Student’s t-test. (C,D) Viaat-Cre;Shank3Δ14–16 mice (8–9 weeks for C and 12–14 weeks for D) show hypoactivity in the open-field test (C) and during the first 6 h but not the last 68 h in Laboras cages (long-term monitoring; D). n = 18 (WT), 15 (cKO) for open-field, 15 (WT), 13 (cKO) for Laboras, *P < 0.05, ***P < 0.001, ns, not significant, repeated measures two-way ANOVA (for the left panels in open-field and Laboras results; genotype p values = 0.0006 and 0.7414, time × genotype p values = 0.0454 and 0.0002, respectively), Student’s t-test.