Table 1.

Summary of electrophysiological and behavioral phenotypes of global Shank3^Δ14–16 and Viaat-Cre;Shank3^Δ14–16 mice.

			Shank3 exons 14-16 global KO		Shank3 exons 14-16 Viaat cKO
Electrophysiology	Brain region	Measurement	Frequency	Amplitude	Frequency	Amplitude
	Dorsolateral striatum	mEPSC	↓	↓	↓	↓
		mIPSC	-	-	-	-
Behavior	Behavioral domain	Behavioral test	Shank3 exons 14-16 global KO		Shank3 exons 14-16 Viaat cKO
	Social interaction	3-chamber	-		-
		Direct	Total interaction ↑		Total interaction ↑
		interaction	Nose-to-nose ↑		Nose-to-nose, -
			Following ↑		Following, -
	Social communication	Adult USV (courtship)	↓		↓
	Repetitive behavior	Laboras	Self-grooming ↑		Rearing ↑
			Climbing ↓		Climbing ↓
		Self-grooming (w/o bedding)	↑		-
		Repetitive behavior	Self-grooming ↑		Self-grooming ↑
		(with bedding)	Digging ↓		Digging ↓
	Locomotor activity	Laboras (first 6 h)	↓		↓
		Open-field	↓		↓
	Anxiety-like behavior	Open field (center time)	-		↓
		Elevated plus-maze (time in open arms)	↑		-
		Light/dark box (time in light chamber)	↓		↓

This table summarizes only the increases or decreases of various electrophysiological and behavioral phenotypes in a given mouse line relative to wild-type (WT)/control mice, but is not intended to compare the phenotypic severities across different mouse lines. -, no significant change; up and down arrows, increases and decreases.