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. 2018 Oct 9;9:1051. doi: 10.3389/fphar.2018.01051

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Copyright © 2018 Wang, Huang, Fan, He, Zhao, Shu, Li, Liu, Lu, Xiao and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The overview of metabolic imbalances in rheumatoid arthritis (RA) patients and the action mechanism of methotrexate (MTX) combined with tripterygium glycosides tablets (TGT_S) to treat RA. The color of the font represents the regulation direction of metabolites; the blue represent elevated levels of the RA patients compared to healthy controls; the red represents reduced levels of RA patients compared to healthy controls. Dashed line represents the action site of combination therapy.