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. 2018 Oct 2;2018:8308671. doi: 10.1155/2018/8308671

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Copyright © 2018 Wenjing Sun et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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HFD could increase the levels of CA and DCA, leading to upregulating the expression of small intestinal TPH1 and then increase the serotonin concentration of small intestine, which fastens the gastrointestinal motility. Furthermore, after receiving FMT, the decreased levels of CA and DCA could downregulate the expression of TPH1 and reduce the serotonin concentration in the gut and then relieve the gastrointestinal dysmotility. In addition, DCA can also promote gastrointestinal motility.