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Overview of ZIP. (a) Topological model of ZIP. ZIP is composed of 8 TMDs with a large N-terminal domain including a PCD and HRD as well as a CTD. The pseudosymmetric TMs are shown in the same color. Zn2+ binds to the active site made up of TMD4 and 5 via the conserved HNXXD and HEXXH motifs. (b) Transport mechanism. ZIP has two major conformations, the inward-open and the outward-open conformations. The PAL motif and TMDs are involved in dimerization.
