Table 2.
Organ weights following the 14-d treatment of intact female rats with acetic acid-induced gastric ulcers with lansoprazole and hydroalcoholic extract from the leaves of Eugenia punicifolia
Treatment |
|||
Vehicle | Lansoprazole | HEEP | |
Organ weights, g | |||
Heart | 3.43 ± 0.05 | 3.50 ± 0.03 | 3.44 ± 0.06 |
Kidneys | 4.74 ± 0.03 | 4.81 ± 0.04 | 4.69 ± 0.06 |
Lung | 4.23 ± 0.07 | 4.53 ± 0.06 | 4.01 ± 0.30 |
Liver | 10.67 ± 0.14 | 10.90 ± 0.10 | 10.61 ± 0.09 |
Spleen | 2.56 ± 0.06 | 2.56 ± 0.07 | 2.48 ± 0.06 |
Biochemical parameters | |||
Glucose, mg/dL | 119.10 ± 3.27 | 116.90 ± 3.21 | 122.30 ± 3.34 |
Creatinine, mg/dL | 0.45 ± 0.02 | 0.41 ± 0.02 | 0.45 ± 0.01 |
Urea, mg/dL | 49.50 ± 3.36 | 53.29 ± 1.11 | 53.70 ± 3.20 |
γ-GT, U/L | < 1.0 | < 1.0 | < 1.0 |
AST, U/L | 202.70 ± 12.73 | 198.40 ± 18.84 | 162.10 ± 7.24 |
ALT, U/L | 57.00 ± 3.40 | 60.57 ± 3.59 | 65.86 ± 2.79 |
Vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Data were collected at the end of treatment. Results are expressed as the means ± standard error of the mean for each group (n = 7-8). Statistical significance was determined using one-way ANOVA followed by Dunnett's test. No significant differences vs vehicle were noted; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; γ-GT: Gamma-glutamyl transpeptidase. HEEP: Hydroalcoholic extract from the leaves of Eugenia punicifolia.