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3D macroporous brain probes reprinted with permission from Xie et al. Schematics of (a) insertion scheme and (b) 3D spherical structure with flexible arms that are designed to protrude through the glial scar and form a close contact to the neurons; and (c) immunohistochemistry (IHC) of the insertion site demonstrating an extremely low immune response with a high neuronal density [85].
