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. 2017 Aug 30;8(9):266. doi: 10.3390/mi8090266

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Surface acoustic wave (SAW) stage used to lyse cells: (a) interdigitated transducer (IDT) used to generate the SAW; (b) the phononic lattice absorbs SAWs in a frequency-dependent manner. This acts to create a rotational movement within the droplet and results in shear flows that contribute to the disruption of the cell membrane. (c) The sequence of images shows a droplet of cells undergoing SAW-induced mechanical lysis. Reprinted with permission from [53]. Copyright (2015) American Chemical Society.