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Simple schematic representing the main microenvironments of a solid tumor. Blood flow becomes negligible at the hypoxic-angiogenic transition due to the tumor interstitial fluid pressure (TIFP) which constitutes a barrier to the diffusion of conventional therapeutic agents towards the hypoxic regions. Oxygen concentration is maximal at the hypoxic-angiogenic transition and decreases gradually to zero (anoxic) past the hypoxic-necrotic boundaries.
