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. 2018 Jun 18;8(5):341–347. doi: 10.1016/j.jpha.2018.06.002

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© 2018 Xi'an Jiaotong University. Production and hosting by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — Representative MRM chromatograms of (A) double blank plasma (without asenapine and asenapine13C-d3), (B) blank plasma spiked with asenapine13C-d3 (25.0 ng/mL), (C) asenapine (0.050 ng/mL), N-desmethyl asenapine (20.0 ng/mL) and asenapine-N-glucuronide (20.0 ng/mL) and asenapine13C-d3 (25 ng/mL), (D) asenapine (20.0 ng/mL), N-desmethyl asenapine (20.0 ng/mL) and asenapine-N-glucuronide (20.0 ng/mL) and asenapine13C-d3 (25 ng/mL) and (E) real subject sample at C_max after oral administration of 10 mg dose of asenapine.