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. Author manuscript; available in PMC: 2018 Oct 16.
Published in final edited form as: Proc IEEE Inst Electr Electron Eng. 2016 Mar 24;105(3):482–495. doi: 10.1109/JPROC.2016.2531000

Fig. 4.

Fig. 4

The null distribution of the p-values obtained from pDis analysis for all KEGG signaling pathway (139 pathways) in 1,000 iterations. The input gene expression values were chosen from a random normal distribution with mean of 0 and standard deviation of 1. The histogram shows the null distribution of the pooled p-values. Uniform distributions were also obtained for each individual target pathway (data not shown). The uniform distributions prove that pDis analysis does not produce any more false positives than expected.