Figure 3.

Average corticosteroid release from injectable liquid polymer at concentrations of 1mg/mL (Light shade circles) and 100mg/mL (Dark shade triangles) at 25°C. Release of corticosteroids shows a slower release profile at high polymer concentrations in an injectable fluid formulation of cyclodextrin polymers in a clinically relevant timeline of 1 week. High concentrations of liquid polymer shows strong binding to the affinity polymer with no measurable drug release. Release from a chemically similar polymer (dextran) showed burst and depletion in the first three days of release independent of polymer concentration.