Fig. 5.

Influences of different inhibitors on the enzymes involved in central carbon metabolism. GLK glucokinase, PGI phosphoglucose isomerase, ZWF glucose 6-phosphate dehydrogenase, PGL phosphogluconolactonase, EDD 6-phosphogluconate dehydratase, PFK phosphofructokinase, FBP fructose-bisphosphate aldolase, GAP glyceraldehyde 3-phosphate dehydrogenase, EDA 2-keto-3-deoxy-phosphogluconate aldolase, PGK phosphoglycerate kinase, PGM phosphoglyceromutase, ENO enolase, PYK pyruvate kinase, PDC pyruvate decarboxylase, ADHA alcohol dehydrogenase I, ME malic enzyme, PDHC pyruvate dehydrogenase complex, PPC phosphoenolpyruvate carboxylase, CS citrate synthase, AH aconitate hydratase, ICDH isocitrate dehydrogenase, KDHC E3 subunit α-ketoglutarate malate dehydrogenase, SCS succinyl-CoA synthetase, SDH succinate dehydrogenase, FUM fumarase, MDH malate dehydrogenase. Fold-change values of the enzymes under the challenge of different inhibitors are marked beside the enzyme names. Symbol “*” denotes p value < 0.0001