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. 2018 Oct 16;6:104. doi: 10.1186/s40478-018-0606-1

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — SOCS3 inhibits the expression of reactive astrocyte markers. a, Heatmaps of genes belonging to the pan, A1 or A2 reactive astrocyte cassettes. SOCS3 decreases the expression of markers belonging to all categories, in APP astrocytes. Color scales represent mean-centered expression (log2-transformed). Wald test. b, Dendrogram obtained by WGCNA with the significant module indicated with an arrow. c, The significant WGCNA module is mainly formed by genes down-regulated by SOCS3. ANOVA. N = 7-4-5. * p < 0.05, ** p < 0.01, *** p < 0.001