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. Author manuscript; available in PMC: 2018 Oct 16.
Published in final edited form as: Annu Rev Microbiol. 2017 Sep 8;71:79–98. doi: 10.1146/annurev-micro-090816-093512

Figure 4.

Figure 4

Model for the biosynthesis of the secondary cell wall polysaccharide (SCWP) in B. anthracis. (a) Putative synthesis of undecaprenyl-pyrophosphate-linked SCWP trisaccharide subunits that are modified with galactosyl, ketal pyruvyl, or acetyl groups, translocated across the membrane by Wzx-like and polymerized by Wzy-like catalysts. The SCWP is finally linked to peptidoglycan by LCP enzymes. (b) Gene clusters contributing to SCWP synthesis include slc (see Figure 2b) as well as scwp1, scwp2, and sps (surface polysaccharide). Genes in gray flank gene clusters but are not part of them. The GenBank identifiers of flanking genes are underneath gray gene symbols. Bracketed numbers in both panels indicate putative chemical reactions and enzymes for SCWP synthesis.