Table 1:
Distribution of asthma, wheezing, allergic disease and serum IgE concentrations by Measles, Mumps and Rubella (MMR) vaccination
| Received MMR vaccine before age 5 years |
Received MMR vaccine at age 12 years |
||||||
|---|---|---|---|---|---|---|---|
| Variable | Overall | No | Yes | p * | No | Yes | p * |
| Age 5 years | |||||||
| Asthma (questionnaire), % (n/N) | 14.3 (78/546) |
36.4 (8/22) |
13.4 (70/524) |
0.003 | |||
| Current wheezing without a cold (physical exam), % (n/N) | 5.5 (30/549) |
14.3 (3/21) |
5.1 (27/528) |
0.07 | |||
| Hypersensitivity/allergy (questionnaire), % (n/N) | 13.6 (74/544) |
42.9 (9/21) |
12.4 (65/523) |
<0.001 | |||
| Eczema (physical exam), % (n/N) | 8.8 (48/547) |
9.5 (2/21) |
8.7 (46/526) |
0.90 | |||
| Age 7 years | |||||||
| Current wheezing without a cold (physical exam), % (n/N) | 7.7 (40/518) |
5.6 (1/18) |
7.8 (39/500) |
0.73 | |||
| Eczema (physical exam), % (n/N) | 9.5 (49/518) |
11.1 (2/18) |
9.4 (47/500) |
0.81 | |||
| Serum total IgE (kUA/L), median (N) | 21.9 (425) |
30.5 (15) |
21.75 (410) |
0.10 | |||
| Positive serum grass IgE (> 0.35 kUA/L), % (n/N) | 8.9 (38/425) |
26.7 (4/15) |
8.3 (34/410) |
0.01 | |||
| Age 13 years | |||||||
| Asthma ever (questionnaire), % (n/N) | 17.0 (83/489) |
47.4 (9/19) |
15.7 (74/470) |
<0.001 | 12.7 (9/71) |
17.7 (74/418) |
0.30 |
| Wheezing in the past 12 months (questionnaire), % (n/N) | 6.8 (33/489) |
10.5 (2/19) |
6.6 (31/470) |
0.50 | 8.5 (6/71) |
6.5 (27/418) |
0.54 |
| Wheezing at rest in the past 12 months (ISAAC video questionnaire), % (n/N) | 3.5 (17/489) |
5.3 (1/19) |
3.4 (16/470) |
0.67 | 2.8 (2/71) |
3.6 (15/418) |
0.74 |
| Current wheezing without a cold (physical exam), % (n/N) | 2.0 (10/489) |
0.0 (0/19) |
2.1 (10/470) |
0.52 | 4.2 (3/71) |
1.7 (7/418) |
0.16 |
| Allergic rhinoconjunctivitis symptoms in the past 12 months (questionnaire), % (n/N) | 12.1 (59/489) |
21.1 (4/19) |
11.7 (55/470) |
0.22 | 14.1 (10/71) |
11.7 (49/418) |
0.57 |
| Eczema ever (questionnaire), % (n/N) | 20.9 (102/489) |
31.6 (6/19) |
20.4 (96/470) |
0.24 | 19.7 (14/71) |
21.1 (88/418) |
0.80 |
| Reaction to any allergen in skin prick test, % (n/N) | 38.7 (189/489) |
52.6 (10/19) |
38.1 (179/470) |
0.20 | 36.6 (26/71) |
39.0 (163/418) |
0.70 |
| Eczema (physical exam), % (n/N) | 7.8 (38/488) |
11.1 (2/18) |
7.7 (36/470) |
0.59 | 5.7 (4/70) |
7.8 (34/418) |
0.48 |
*
Binary outcomes were tested using chi square and continuous outcomes (total IgE at age 7) were tested using Wilcoxon rank sum test