Table 2:
Cohort characteristics by MMR vaccination at age 5
| Received MMR vaccine before age 5 |
|||||
|---|---|---|---|---|---|
| Variables | Overall | No | Yes | p * | |
| Sex, girls, % (n/N) | 47.0 (261/555) | 31.8 (7/22) | 47.7 (254/533) | 0.15 | |
| Age at 5-year examination, median (N) | 4.95 (555) | 4.93 (22) | 4.95 (533) | 0.51 | |
| Age at 7-year examination, median (N) | 7.53 (518) | 7.51 (18) | 7.53 (500) | 0.45 | |
| Age at 13-year examination, median (N) | 13.22 (489) | 13.28 (19) | 13.22 (470) | 0.73 | |
| Premature birth (duration of gestation <37 weeks), % (n/N) | 2.0 (11/555) | 0.0 (0/22) | 2.1 (11/533) | 0.50 | |
| Maternal smoking during pregnancy, % (n/N) | 164/555 (29.5) | 8/22 (36.4) | 156/533 (29.3) | 0.48 | |
| Birth weight (g), median (N) | 3750 (555) | 4025 (22) | 3700 (533) | 0.01 | |
| IgE concentration in cord blood (kUA/L)1, median (N) | 0.07 (494) | 0.11 (20) | 0.07 (474) | 0.12 | |
| Total months of breastfeeding, median (N) | 9 (552) | 7.75 (22) | 9 (530) | 0.32 | |
| Number of older siblings (at age 5) | 0, % (n/N) | 24.3 (135/555) | 9.1 (2/22) | 25.0 (133/533) | 0.39 |
| 1, % (n/N) | 34.1 (189/555) | 40.9 (9/22) | 33.8 (180/533) | ||
| 2, % (n/N) | 28.1 (156/555) | 31.8 (7/22) | 28.0 (149/533) | ||
| >=3, % (n/N) | 13.5 (75/555) | (18.2 (4/22) | 13.3 (71/533) | ||
| Number of younger siblings (at age 5) | 0, % (n/N) | 61.4 (340/554) | 72.7 (16/22) | 60.9 (324/532) | 0.40 |
| 1, % (n/N) | 33.9 (188/554) | 27.3 (6/22) | 34.2 (182/532) | ||
| 2, % (n/N) | 4.7 (26/554) | 0.0 (0/22) | 4.9 (26/532) | ||
| Parental smoking in the home at age 5 years, % (n/N) | 26.5 (146/552) | 36.4 (8/22) | 26.0 (138/530) | 0.28 | |
| Use of day care at age 5 years, % (n/N) | 92.4 (507/549) | 90.5 (19/21) | 92.4 (488/528) | 0.74 | |
| Received MMR vaccine at around age 12 years, % (n/N) | 85.5 (418/489) | 68.4 (13/19) | 86.2 (405/470) | 0.03 | |
| Family history of chronic bronchitis or asthma | No, % (n/N) | 56.9 (278/489) | 26.3 (5/19) | 58.1 (273/470) | 0.01 |
| From one parent, % (n/N) | 33.3 (163/489) | 63.2 (12/19) | 32.1 (151/470) | ||
| From both parents, % (n/N) | 4.7 (23/489) | 0.0 (0/19) | 4.9 (23/470) | ||
| Do not know, % (n/N) | 5.1 (25/489) | 10.5 (2/19) | 4.9 (23/470) | ||
| Family history of eczema in children, allergic eczema and hay fever | No, % (n/N) | 38.0 (186/489) | 42.1 (8/19) | 37.9 (178/470) | 0.85 |
| From one parent, % (n/N) | 44.2 (216/489) | 47.4 (9/19) | 44.0 (207/470) | ||
| From both parents, % (n/N) | 11.2 (55/489) | 5.3 (1/19) | 11.5 (54/470) | ||
| Do not know, % (n/N) | 6.5 (32/489) | 5.3 (1/19) | 6.6 (31/470) | ||
| Family history of allergy | No, % (n/N) | 48.0 (234/488) | 36.8 (7/19) | 48.4 (227/469) | 0.68 |
| From one parent, % (n/N) | 32.8 (160/488) | 42.1 (8/19) | 32.4 (152/469) | ||
| From both parents, % (n/N) | 7.8 (38/488) | 5.3 (1/19) | 7.9 (37/469) | ||
| Do not know, % (n/N) | 11.5 (56/488) | 15.8 (3/19) | 11.3 (53/469) | ||
*
Categorical variables were tested using chi square and continuous variables were tested using Wilcoxon rank sum test
1
3 children with IgA > 50 µg/ml were excluded